� The drug zyloprim, which lowers uric acid levels, appears to reduce blood pressure level in adolescents with fresh diagnosed hypertension, according to a preliminary report in the August 27 publication of JAMA.
Hypertension is commonly associated with hyperuricemia (elevated blood level of uric acid, a by-product of normal chemical processes in the body and found in the piddle and pedigree). Early research suggested uric acid had a causal role in hypertension, but an natural elevation of uric acid in hypertension could be a consequence of several factors, and hyperuricemia is non considered a true hazard factor for hypertension, according to background information in the article. Recent studies have challenged this impression, including evidence supporting a causal part of uric acid in hypertension, as indicated from experimental studies in science laboratory animals.
Daniel I. Feig, M.D., Ph.D., of the Baylor College of Medicine, Houston, and colleagues conducted a randomised, placebo-controlled "crossing over" trial to determine whether lowering uric acid levels with the drug zyloprim would reduce blood pressure level (BP) in hyperuricemic adolescents (age 11-17 years) with newly diagnosed hypertension. Thirty patients were randomly assigned to get either allopurinol or placebo, twice day-after-day for four weeks. This was followed by a two week "washout" point during which the patients received neither allopurinol nor placebo, after which they received the other therapy (allopurinol or placebo) they had not received sooner, for tetrad more weeks.
Allopurinol treatment was associated with a significant decrease in casual and ambulatory systolic and diastolic BP. The median decrease in casual BP during zyloprim treatment was -6.9 mm Hg for systolic and -5.1 mm Hg for diastolic BP; for placebo, the various changes were -2.0 and -2.4. The average changes in 24-hour ambulatory BP during zyloprim were -6.3 mm Hg, systolic; -4.6, diastolic BP. Systolic BP increased slightly during the placebo phase by 0.8 mm Hg and diastolic BP slightly decreased by 0.3. The decrease in ambulatory BP directly correlated with zyloprim treatment. Twenty of the 30 participants achieved normal BP by casual and ambulatory criteria during the allopurinol form, whereas only 1 of 30 achieved normal BP during the placebo phase.
"The results of this study represent a potentially new curative approach, that of control of a biochemical suit of hypertension, rather than nonspecifically lowering elevated BP. Although not representing a fully developed therapeutic strategy, this report raises an alternative strategy that may prove to be more effective than currently uncommitted options," the authors spell.
"Despite these findings, this clinical trial is a small i and allopurinol is not indicated for the treatment of hypertension in adolescents or other populations. The potential inauspicious effects of allopurinol, including gastrointestinal complaints and especially Stevens-Johnson syndrome [a severe, allergic reaction], make allopurinol an untempting alternative to available antihypertensive medications. More clinical trials are needed to determine the reproducibility of the data and whether it can be generalized to the bigger hypertensive population. Nevertheless, the observation that lowering uric acid can reduce BP in adolescents with new diagnosed high blood pressure raises intriguing questions nearly its part in the pathogenesis of hypertension," the researchers conclude.
(JAMA. 2008;300[8]:924-932.)
JAMA
More info
Wednesday, 3 September 2008
Wednesday, 6 August 2008
Smoking Predicts Increased Stroke Risk For Your Spouse
�Although Second Hand Smoke (SHS) is widely recognized as a risk factor for coronary thrombosis heart disease, there receive been few studies investigation the association of SHS and
Friday, 27 June 2008
DMX Arrested Again -- What Else Is New?
Don Imus would have a bloody field day with this one: DMX got arrested ... for the third time since May. He was popped in Miami yesterday for driving without a valid driver's license, according to the local po-po. Why he would do this after getting collared in Arizona on a suspended license just a month ago is anyone's guess. Of course, he then got nabbed three days later in 'Zona for animal cruelty and felony drug possession charges.
Story developing ...
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Thursday, 19 June 2008
Mariah Carey wants a famous partner
Singer Mariah Carey has revealed that she prefers to date famous men, because they are more likely to "fully understand" her.
The singer told Allure magazine that she wants to find a partner who understands the world of celebrity.
Carey said: "That's a big deal for me - feeling like somebody else can't fully understand me because they're not in showbusiness."
"It shouldn't matter, but it does, because the energy it takes to be 'on' is a lot."
The singer also revealed that she is looking for "someone who I would know is going to take care of me emotionally, they're going to understand who I am".
Speaking about her fans, she said: "What's weird about that is being onstage, and the love that you get, and the adoration that you feel from your real fans. It's hard for a partner to compete - just imagine."
The singer told Allure magazine that she wants to find a partner who understands the world of celebrity.
Carey said: "That's a big deal for me - feeling like somebody else can't fully understand me because they're not in showbusiness."
"It shouldn't matter, but it does, because the energy it takes to be 'on' is a lot."
The singer also revealed that she is looking for "someone who I would know is going to take care of me emotionally, they're going to understand who I am".
Speaking about her fans, she said: "What's weird about that is being onstage, and the love that you get, and the adoration that you feel from your real fans. It's hard for a partner to compete - just imagine."
Friday, 13 June 2008
Martha Wainwright emerges from shadow of famous clan to find herself
TORONTO - Martha Wainwright is used to being referred to as the daughter or the sister of her more famous family members, but it's the shadow of former lovers that looms large on her second solo disc, a collection of tortured tales filled with heartache and loneliness.
The quirky singer-songwriter wears her heart on her sleeve with the provocatively titled, "I Know You're Married But I've Got Feelings Too," an emotional roller-coaster filled with dark humour and such melodramatic pronouncements as: "My heart was made for bleeding all over you."
"I certainly cry a lot," Wainwright admits of the raw emotion she puts on display, backed by swirling melodies and layered instrumentation.
"In general, I think that the songs were about my own autobiographical life (which) was scary and lonely as it usually is when you're young and trying to find yourself in a world of egomaniacs ... (And then) you get up on stage and you're trying to get loved and appreciated and it doesn't always work."
"You have to expose yourself a lot and so I think that early on that really defined my style of songwriting and then also my relationship to my family because that's always interested me."
Her wildly talented family is a fascination for many, and is famously the reason for Wainwright's belated foray into the musical spotlight herself. She spent much of her youth supporting the musical projects of folk-singer parents Loudon Wainwright III and Anna McGarrigle and her brother, singer-songwriter Rufus Wainwright, with self-doubt serving as a constant personal obstacle.
Wainwright, 32, says she's finding her voice now and is excited by the stronger and more poised approach that distinguishes this latest outing from her nonetheless accomplished 2005 debut disc, simply titled "Martha Wainwright."
"It's kind of like being a rich kid and never having a job yourself," she says of her earlier insecurities.
"That makes you sometimes lack confidence in some way because you feel like you can never sort of catch up. I think that that's always been something that's haunted me but I think that's certainly less, less and less and less. And now that I just go on the road and I play my own shows and I write songs and I work really, really hard, all of that other stuff sort of fades away."
"As on the previous disc, brother Rufus appears singing back-up, and brought an undercurrent of sibling rivalry to the studio sessions.
"I always call Rufus when I run out of ideas because he never runs out of ideas ... and it's always something that is completely off-the-wall. And when I have him sing back-up I don't really tell him what to do because I don't think that's really going to work," Wainwright says laughing.
"Because he's still my older brother. It's more like trying to like let him have free reign. Then he leaves and then I edit it! So it's a system."
"Family also appears by way of Wainwright's husband, Brad Albetta, who produced most of the disc. Wainwright credits him with helping her find the courage to cut her own path to begin with, noting he ushered her through her debut, as well, and helped close a chapter in her life that included a seemingly endless stream of unrequited love."
"I was very lonely and very sad in many ways and so it was nice to have someone...in the work situation that believed in me and I think that gave me more of a sense of confidence to sort of continue," says Wainwright, whose wedding to Albetta last September was said to be a star-packed affair including guests Emmylou Harris, Linda Thompson and Jimmy Fallon.
Special guests on her second disc include friends Pete Townshend of the Who, Donald Fagen of Steely Dan and Garth Hudson of the Band.
Wainwright says her friendship with Townshend began several years ago in London when she received a phone call out of the blue inviting her to appear on an online music show he tapes out of his living room. To her surprise, he was a fan and jumped in with his guitar as she performed. They've been friends ever since, with Townshend providing mentorship and encouragement that now has Wainwright contemplating her musical ambitions in the grandest of scales.
"I'm still trying to create my story in the history of music amongst my family and other greats - which is so interesting about having people like Pete Townshend and Donald Fagen (as musical guests)," says Wainwright, who splits her time between Montreal and Brooklyn, N.Y.
"You get a sense of the history of music and that story and it's great to feel like you could maybe pop in somewhere on that line."
News from �The Canadian Press, 2008
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Friday, 6 June 2008
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Bob Brown
Artist: Bob Brown
Genre(s):
Techno
Discography:
Series Primary Yellow (FW02)
Year: 1999
Tracks: 4
Series Primary Blue
Year: 1999
Tracks: 4
Gallagher & Appleton tie the knot
Oasis frontman Liam Gallagher has married his long-term partner, singer Nicole Appleton.
According to reports, the couple tied the knot in a low-key civil ceremony in London on Valentine's Day.
The wedding reception reportedly took place at the five-star Landmark Hotel in London.
Appleton has previously spoken about marrying Gallagher, saying: "Marriage is important to me and I love the idea of being married."
The couple, who have been together for nearly eight years, have a seven-year-old son together.
According to reports, the couple tied the knot in a low-key civil ceremony in London on Valentine's Day.
The wedding reception reportedly took place at the five-star Landmark Hotel in London.
Appleton has previously spoken about marrying Gallagher, saying: "Marriage is important to me and I love the idea of being married."
The couple, who have been together for nearly eight years, have a seven-year-old son together.
Spears' family claim Dr Phil betrayed them
Britney Spears' parents have accused television therapist Dr Phil McGraw of betraying their trust by speaking publicly about his visit with their daughter.
The therapist went to see Spears, at the request of her family, while she was in hospital last week after being admitted for evaluation following a custody dispute at her home.
Lou Taylor, a spokesperson for the Spears family, told NBC's 'Today' that Spears' parents had asked McGraw to visit her as a private favour.
Taylor said: "The family basically extended an invitation of trust as a resource to support them, not to make a public statement."
She also claimed that McGraw's intervention had damaged Spears' relationships with her mother Lynne and her younger sister Jamie Lynn.
Taylor said that the family "were looking for support here, not to add to the trouble that is already upon them".
After his visit to the singer, McGraw issued a statement saying that Spears was "in dire need of medical and psychological intervention".
Speaking on 'Entertainment Tonight', the television therapist said: "Somebody needs to step up and provide a vector to get this young woman into some quality care."
Yesterday, various news reports suggested that Spears' new boyfriend, paparazzo Adnan Ghalib, was trying to sell semi-nude pictures of her to tabloid publications.
The therapist went to see Spears, at the request of her family, while she was in hospital last week after being admitted for evaluation following a custody dispute at her home.
Lou Taylor, a spokesperson for the Spears family, told NBC's 'Today' that Spears' parents had asked McGraw to visit her as a private favour.
Taylor said: "The family basically extended an invitation of trust as a resource to support them, not to make a public statement."
She also claimed that McGraw's intervention had damaged Spears' relationships with her mother Lynne and her younger sister Jamie Lynn.
Taylor said that the family "were looking for support here, not to add to the trouble that is already upon them".
After his visit to the singer, McGraw issued a statement saying that Spears was "in dire need of medical and psychological intervention".
Speaking on 'Entertainment Tonight', the television therapist said: "Somebody needs to step up and provide a vector to get this young woman into some quality care."
Yesterday, various news reports suggested that Spears' new boyfriend, paparazzo Adnan Ghalib, was trying to sell semi-nude pictures of her to tabloid publications.
R. Kelly in 'vile' sex video: prosecutors
CHICAGO - R. Kelly produced and starred in a "vile, disturbing and disgusting" sex video with an underaged girl, prosecutors told a jury today.But lawyers defending the Grammy Award-winning artist said the 26-minute tape shows neither Kelly nor his alleged victim, and where the video came from remains a mystery.The exchanges came in the opening statements of Kelly's trial on 14 counts of videotaping, producing or soliciting child pornography. If convicted of all charges, the 41-year-old performer, whose given name is Robert Kelly, could be sentenced to up to 15 years in prison.The tape at the center of the case was to be shown in court."You will see the sex acts he commands her to do," Shauna Boliker of the Cook County state's attorney's office told the jury. "Acts you have never seen before. Vile, disturbing and disgusting sex acts, actions that were choreographed, produced and starred in by Robert Kelly," she said."The case will unfold before you frame by disgusting frame," she added, with the girl "doing what she's told. There's no feeling in her face. It is clear she is an underaged girl" whom Kelly met when she was 12.
Prosecutors say the tape was made between January 1998 and November 2000, when she was 13 or 14.Boliker told the jury that the girl - now in her 20s - will not testify for the prosecution. She has said it is not her on the tape and refused to testify against Kelly, but she may be called as a defence witness, court records indicate.'Copy of a copy of a copy'"Robert Kelly is not on that tape," said defence lawyer Sam Adam Jr., nor is the alleged victim."Where does this tape comes from? They don't know," he said. "There isn't an original of this tape. The tape you're going to see here is at best a copy of a copy of a copy of the original."Adam said the FBI reviewed the tape, which was turned over to police by the Chicago Sun-Times in 2002, and the agency concluded that they could not identify Kelly as being on the tape."It has gone through five or six generations and there are no identifying marks," he added.He said police took pictures of Kelly's body stripped to his undershorts that show a "significant mole" on his lower back, implying that the tape does not show a man with a mole in that spot.The trial before Judge Vincent Gaughan of the Cook County Criminal Court got underway six years after Kelly was charged. The jury consists of men and women, black and white, and the trial may last up to seven weeks.The accusations prompted some radio stations to stop playing Kelly's songs, but it did not derail his career. He has earned millions of dollars from concert tours and album sales while being free on $750,000 bond.After singing for change on Chicago subway platforms, Kelly shot to fame in the early 1990s with hits like Sex Me and Bump n' Grind.The carnality of his early lyrics gave way to wholesomeness with the 1996 single I Believe I Can Fly which earned Kelly three Grammy Awards. He has received 20 Grammy nominations.- REUTERS
Prosecutors say the tape was made between January 1998 and November 2000, when she was 13 or 14.Boliker told the jury that the girl - now in her 20s - will not testify for the prosecution. She has said it is not her on the tape and refused to testify against Kelly, but she may be called as a defence witness, court records indicate.'Copy of a copy of a copy'"Robert Kelly is not on that tape," said defence lawyer Sam Adam Jr., nor is the alleged victim."Where does this tape comes from? They don't know," he said. "There isn't an original of this tape. The tape you're going to see here is at best a copy of a copy of a copy of the original."Adam said the FBI reviewed the tape, which was turned over to police by the Chicago Sun-Times in 2002, and the agency concluded that they could not identify Kelly as being on the tape."It has gone through five or six generations and there are no identifying marks," he added.He said police took pictures of Kelly's body stripped to his undershorts that show a "significant mole" on his lower back, implying that the tape does not show a man with a mole in that spot.The trial before Judge Vincent Gaughan of the Cook County Criminal Court got underway six years after Kelly was charged. The jury consists of men and women, black and white, and the trial may last up to seven weeks.The accusations prompted some radio stations to stop playing Kelly's songs, but it did not derail his career. He has earned millions of dollars from concert tours and album sales while being free on $750,000 bond.After singing for change on Chicago subway platforms, Kelly shot to fame in the early 1990s with hits like Sex Me and Bump n' Grind.The carnality of his early lyrics gave way to wholesomeness with the 1996 single I Believe I Can Fly which earned Kelly three Grammy Awards. He has received 20 Grammy nominations.- REUTERS
Quaid joins Grey's Anatomy star in thriller
Dennis Quaid has joined the cast of the new film 'Legion' which co-stars 'Grey's Anatomy's Kate Walsh, who plays Addison in the medical drama.
Variety says the film, which marks the feature directorial debut of Scott Stewart, also stars Lucas Black and 'The Da Vinci Code's Paul Bettany.
The thriller focuses on Bettany's character, the archangel Michael, the only one standing between mankind and an apocalypse, after God loses faith in humanity.
Shooting is about to get underway in New Mexico.
Variety says the film, which marks the feature directorial debut of Scott Stewart, also stars Lucas Black and 'The Da Vinci Code's Paul Bettany.
The thriller focuses on Bettany's character, the archangel Michael, the only one standing between mankind and an apocalypse, after God loses faith in humanity.
Shooting is about to get underway in New Mexico.
Randy Katana Presents Nick Larson
Artist: Randy Katana Presents Nick Larson
Genre(s):
Trance
Discography:
Presents Nick Larson
Year: 2007
Tracks: 2
Fdv6 (Legacy)
Year: 2007
Tracks: 2
Ali Lohan: ‘I got picked on by disgusting kids at school’
Lindsay Lohan’s sister Ali has revealed she once got picked on by “disgusting kids” at school.
The 14-year-old — whose E! reality show, Living Lohan with manager-mom Dina, debuts on Memorial Day — says, “A little while ago … a couple of girls in school made up a video of me and put it up on YouTube.
“They used disgusting words. Like if my mom ever heard me say that stuff, I’d be grounded for life! … They’re disgusting kids. I got really aggravated.”
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Ashlee and Pete Wentz expecting first child
New York (ANI): Ashlee Simpson and fiance Pete Wentz have made sure that their assets are protected just in case their marriage does not work out by signing a pre-nuptial agreement. The couple recently tied the knot, and are rumoured to be expecting their first child together. Wentz told Ryan Seacrest's KIIS-FM radio show that he and Simpson had indeed signed a pre-nup, reports the New York Daily News. "We have signed a pre-nup," he told the radio show. However, he refused to confirm whether or not the couple are indeed pregnant. "This baby has not been confirmed," he said. "The only thing I'm confirming now is that we're in the basement on our honeymoon with these blow-up palm trees," he said
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